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Chronic Respiratory Disease Questionnaire-CRQ

Name of Questionnaire

Chronic Respiratory Disease Questionnaire (CRQ)


The CRQ is an interviewer-administered questionnaire measuring both physical and emotional aspects of chronic respiratory disease.


GH Guyatt MD


Dr. Gordon H. Guyatt
Dept. of Clinical Epidemiology
McMaster University Med. Ctr.
1200 Main Street
Hamilton, Ontario

Contact information

Mrs. Peggy Austin, Dr. Holger Shünemann or Dr. Gordon Guyatt
Dept. of Clinical Epidemiology & Biostatistics
McMaster University
1200 Main Street West, HSC 3V43A
Hamilton, Ontario
PHONE: 905-525-9140 ext. 22154
FAX: 905-540-1144

E-mail , or

Cost & availability

License Agreement required. Please contact the Licensing Officer using the contact information above.



Time to complete

15-25 minutes

Number of items


Domains & categories

4 categories

Name of categories/domains

Dyspnea, fatigue, emotional function, mastery

Scaling of items

Numerical, 7-point modified Likert Scale


Total score and subscores on categories; higher scores indicate better health-related quality of life


a. Test-retest/reproducibility: Reported 1 , 2 , 3 , 23
b. Internal consistency Reported 8 , 9 , 10 , 34


a. Content Reported 3
b. Concurrent Reported 1 , 9 , 16 , 17


Reported 2, 3, 4, 11, 12

A change in the score of 0.5 on the 7 point scale, reflects a clinical significant small change. 4, 11 A change of 1.0 reflects a moderate change and a difference of 1.5 represents a large change. 11

Minimally important difference

Reflected by a change in score of 0.5 on a 7 point scale. 4 , 11 , 24

Research use

Yes, 7 (cystic fibrosis), 13 , 14 , 15

Clinical use



Original: English3

Translations: Danish19, Dutch8, French18, German20, Italian21, Japanese22, Spanish6


  1. Larson JL, Covey MK, Berry JK, Wirtz S, Kim MJ. Reliability and valididty of the Chronic Respiratory Disease Questionnaire. Am J Crit Care Med 1993;147:A350.
  2. Martin LL. Validity and reliability of a quality-of-life instrument. The chronic respiratory disease questionnaire. Clin Nurs Res 1994;3:146-156.
  3. Guyatt GH, Berman LB, Townsend M, Puglsey SO, Chambers LW. A measure of quality of life for clinical trials in chronic lung disease. Thorax 1987;42:773-778.
  4. Redelmeier DA, Guyatt GH, Goldstein RS. Assessing the minimal important difference in symptoms: a comparison of two techniques. J Clin Epidemiol 1996;49:1215-1219.
  5. Wijkstra PJ, Van Altena R, Draan J, Otten V, Postma DS, Koëter GH. Quality of life in patients with chronic obstructive pulmonary disease improves after rehabilitation at home. Eur Respir J 1994;7:269-273.
  6. Guell R, Casan P, Sangenis M, Morante F, Belda J, Guyatt GH. Quality of life in patients with chronic respiratory disease: the Spanish version of the Chronic Respiratory Questionnaire (CRQ). Eur Respir J 1998;11(1):55-60.
  7. Bradley J, Dempster M, Wallace E, Elborn S. The adaptations of a quality of life questionnaire for routine use in clinical practice: the Chronic Respiratory Disease Questionnaire in cystic fibrosis. Qual Life Res 1999;8:65-71.
  8. Wijkstra PJ, Tenvergert EM, VanAltena R, Otten V, Postma D,Kraan J, et al. Reliability and validity of the Chronic Respiratory Questionnaire (CRQ). Thorax 1994;49:465-7.
  9. Harper R, Brazier JE, Waterhouse JC, Walters SJ, Jones NM, Howard P. Comparison of outcome measures for patients with chronic obstructive pulmonary disease (COPD) in an outpatient setting. Thorax 1997;52(10):879-87.
  10. Güell R, Casan P, Sangenis M, Morante F, Belda J, Guyatt GH. The Spanish translation and evaluation of a quality of life questionnaire in patients with chronic obstructive pulmonary disease. Arch Bronchoneumol 1995;31:202-210.
  11. Jaeschke R, Singer J, Guyatt GH. Measurement of health status ascertaining the minimal clinically important difference. Controlled Clin Trials 1989;10:407-415.
  12. Goldstein RS, Gort EH, Stubbing D, Avendano MA, Guyatt GH. Randomised controlled trial of respiratory rehabilitation. Lancet 1994;344:1394-7.
  13. Cook D., Guyatt G, Wong E, Goldstein R, Bedard M, Austin P, Ramsdale H, Jaeschke R, Sears M. Regular versus as-needed short-acting inhaled beta-agonist therapy for chronic obstructive pulmonary disease. American Journal of Respiratory & Critical Care Medicine 2001;163:85-90.
  14. Brightling CE, Monteiro W, Ward R, Parker D, Morgan MD, Wardlaw AJ, Pavord ID. Sputum eosinophilia and short-term response to prednisolone in chronic obstructive pulmonary disease: a randomised controlled trial. Lancet 2000;356(9240):1480-5.
  15. Griffiths TL, Burr ML, Campbell IA, Lewis-Jenkins V, Mullins J, Shiels K, Turner-Lawlor PJ, Payne N, Newcombe RG, Ionescu AA, et al. Results at 1 year of outpatient multidisciplinary pulmonary rehabilitation: a randomised controlled trial. Lancet 2000;355:362-8.
  16. Guyatt GH, King DR, Feeny DH, Stubbing D, Goldstein RS. Generic and specific measurement of health-related quality of life in a clinical trial of respiratory rehabilitation. J Clin Epidemiol 1999;52:187-92.
  17. Guyatt G.H., Townsend M., Keller JL, Singer J. Should study subjects see their previous responses: data from a randomized control trial. J Clin Epidemiol 1989 42:913-20.
  18. Bourbeau J, Rouleau MY, Boucher S. Randomised controlled trial of inhaled corticosteroids in patients with chronic obstructive pulmonary disease. Thorax 1998;53:477-82.
  19. Hansen NC, Evald T, Ibsen TB. Terbutaline inhalations by the Turbuhaler as replacement for domiciliary nebulizer therapy in severe chronic obstructive pulmonary disease [see comments]. Respiratory Medicine 1994;88(4):267-71.
  20. Kirsten DK, Wegner RE, Jorres RA, Magnussen H. Effects of theophylline withdrawal in severe chronic obstructive pulmonary disease. Chest 1993;104:1101-7.
  21. Clini EM, Scalvini S, Simoni, P, Foglio K, Rocchi S, Bruletti G, et al. Cycloergometer effort test evaluation and quality of life in chonic obstructive lung disease. Italian J Chest Dis 1993;47:71-76.
  22. Hajiro T, Nishimura K, Tsukino M, Ikeda A, Koyama H, Izumi T. Comparison of discriminative properties among disease-specific questionnaires for measuring health-related quality of life in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 1998;157:785-90.
  23. Lacasse Y, Wong E, Guyatt G. A systematic overview of the measurement properties of the Chronic Respiratory Questionnaire. Canadian Respiratory Journal 1997;4(3):131-9.
  24. Moran LA, Guyatt GH, et al. Establishing the minimal number of items for a responsive, valid, health-related quality of life instrument. J Clin Epidemiol 2001;54(6): 571-9.

Date of information

April 2002

Comments from developer

Yes (April 2001)

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